LOS ANGELES (AP) ? Stevie Wonder is ending his 11-year marriage to fashion designer Kai Millard Morris.
A spokeswoman for the 62-year-old musician says Wonder filed for divorce Friday in Los Angeles Superior Court. Wonder is asking for privacy for his former wife, his children and his family.
He filed the documents under his real name, Stevland Morris.
Wonder and Millard were wed in 2001. They have two children.
G6 Global, specialist consultants and providers of digital communications equipment including radio and satellite, has established its own private radio communications network in London, on a dedicated frequency bandwidth, in order to alleviate problems associated with operating secure two-way radio communications within the capital.
For a small, select, number of specialist security, counter-terror, close protection and surveillance teams, including a major high-street bank?s high level staff protection team, the network provides secure communications without problems associated with some networks in London and offers high audio quality, wider communication coverage and a higher level of security than some previously available networks.
G6 is restricting the number of users to ensure low contention rates and therefore guarantee service availability. Commenting on the development, Andrew Clark, Managing Director of G6 Global said; ?While the focus is currently on the Olympic Games, London has always presented a difficult operating environment for secure two-way communications due to the sheer volume of traffic and shortage of radio spectrum.
For the future, G6 plans to upgrade the network to provide further availability as required, but it will still be restricted to high level secure requirements. In addition, G6 provides a wide range of handsets and equipment. Majoring on Hytera products, the company is also able to provide a wide range of options from other manufacturers including Icom, Motorola and Kenwood.
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?ISACA Conference in Munich Helps IT Professionals Thwart Cybercrime, Audit the Cloud and Secure Mobile Devices
?Trustmarque becomes official reseller of DigitalPersona multi-factor authentication and access management solutions
?First 5-Megapixel Fisheye Camera launched by Vivotek
?To protect businesses anywhere, anytime, using the Internet Chubb launches IP CCTV
?New generation of mGuard PCI/PCIe cards with front-side SD configuration memory
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Security Bank Loans Grow 29% MANILA, Philippines - Security Bank Corporation reported a healthy 29 percent rise in its loan portfolio during the first semester of 2012 due to the expansion experienced in various industries, most notably in infrastructure, mining, energy and real estate.
Security Bank loans grow 29 percent Security Bank Corp. reported a healthy first semester 29 percent year-on-year rise in its loan portfolio from the expansion experienced in various industries, most notably in infrastructure, mining, energy and real estate.
Jefferson Security Bank Announces Earnings for the Second Quarter and First Half of 2012 and Dividend Payment PJefferson Security Bank reported net income of $161,591 or $0.56 per share, for the second quarter ended June 30, 2012. Net income for the six months ended June 30,
Security Bank loans increase 29% year-on-year SECURITY Bank Corp. reported a healthy first semester 29 percent year-on-year rise in its loan portfolio due to the expansion in various industries, most notably in infrastructure, mining, energy and real estate. The bank?s asset base increased to P235 billion, an 11 percent hike from end of June 2011.
BANK OF AMERICA ASSISTANT GENERAL COUNSEL AND LEADING DATA SECURITY ATTORNEY JOINS REED SMITH Lawfuel.com - Law Firm News Daily - (August 2, 2012, Washington, D.C.). Reed Smith LLP today announced the arrival of senior data security and technology attorney, Timothy J. Nagle in the Global Data Security, Privacy & Management Practice in the firm?s Washington, D.C. office.
Furiex Pharmaceuticals Amends Current Loan and Security Agreement, Adding an Additional $30.0 Million Furiex Pharmaceuticals, Inc. announced today it has restructured its Loan and Security Agreement with MidCap Financial LLC and Silicon Valley Bank to add
Security and Sound Design, a Northern Colorado Security Systems Company, Partners With Page1 for Online Marketing WINDSOR, CO-- - Sound and Security Design, a northern Colorado company that provides at-home entertainment and security systems services, is pleased to announce a partnership with Page1 Online Marketing ...
You know as a speaker you need a book for the added credibility, but somehow you just can?t get yourself to sit down at a computer and write. You are not alone! Most of my clients are speakers who have this same issue. Between running your business, trying to secure lucrative speaking gigs, and general lifecircumstances, finding the time to write a book can be daunting.
But think about this: How hard is it for you to get up in front of a crowd to speak on something you?re passionate about for an hour or two? What if you could simply speak and turn your words into a book?
It is possible to speak your book! One hour?s worth of speaking can easily be turned into 35-40 pages of written text. Speak for only three hours and you have 100 pages you can turn into a decent-sized credibility-boosting book. Here are four easy steps to get your book done in record time:
Step 1: Speak and Record
This is so easy, it?s ridiculous. All you need to do for this step is to record yourself speaking on a topic you?re passionate about. It?s best to record yourself speaking on a subject you want to boost your credibility on the stage, as this will be the basis for the material in your book.
Step 2: Transcribe
Hire a transcriptionist to take your recording from Step 1 and turn it into a manuscript. This manuscript will be very raw, but all this raw material will be the foundation upon which you can build your book.
Step 3: Edit
Because we speak differently than we read, reading a directly spoken manuscript can be very difficult for the brain to comprehend. This is the most complex step to complete, as it will usually require a developmental editor. The good news is you can outsource this portion to a qualified editor and still remain hands-off for this part of the process.
Step 4: Publish
Now comes the fun part?watching your credibility-boosting book take shape before your eyes! The publishing process consists of cover design, layout, setting up for print, and distribution. After this step you?ll have a completed book to proudly display at the back of the room, increase your credibility, and land more speaking gigs and clients than ever before!
Advanced Strategy: Turn your webinars and teleseminars into small lead-generating Kindle books to reach an even larger market with your message!
Speaking a book can be the best option for busy entrepreneurs who prefer the stage to sitting in front of the computer writing for hours on end. If this describes you, speak your book and get it done and distributed faster than you thought possible!
Obese donors increase risk of death for pediatric liver transplant recipientsPublic release date: 1-Aug-2012 [ | E-mail | Share ]
Contact: Dawn Peters sciencenewsroom@wiley.com 781-388-8408 Wiley
Children undergoing liver transplantation are at greater risk of graft loss and death from adult organ donors who are severely obese according to research published in the August issue of Liver Transplantation, a journal of the American Association for the Study of Liver Diseases. The study, funded in part by a grant from the National Institutes of Health (NIH), found that pediatric donor body mass index (BMI) did not increase mortality risk in this pediatric population.
Obesity is a global health concern. A 2008 report from the World Health Organization (WHO) estimates that 1.4 billion adults were overweight, and of these 200 million men and 300 million women were classified as obese. WHO also reports that more than 40 million children under the age of five were overweight in 2010. In the U.S., rates of being overweight or obese have risen in children and now exceed 30% say experts.
Prior research shows the prevalence of overweight and obese donors to adult liver transplant recipients has increased during the last two decades. "Donor BMI is associated with post-transplant obesity, but not survival rates of adult liver recipients," explains lead author Dr. Philip Rosenthal, from the University of California, San Francisco's Benioff Children's Hospital. "Our study is the first to evaluate the impact of donor BMI on pediatric liver transplant recipients."
Using data from the United Network for Organ Sharing (UNOS), researchers identified 3788 pediatric liver transplants between 2004 and 2010. Analysis indicates that adult donor BMI 25-35 kg/m2 was not associated with graft loss or mortality in pediatric liver recipients. However, adult donors with a BMI greater than 35 kg/m2 increased the risk of graft loss and death in children receiving livers, after adjusting for other recipient, donor, and transplant risk factors. The authors found that pediatric donor BMI was not associated with graft or patient survival.
"While we found it common for adult donors to be overweight or obese, our analysis suggests that BMI in the 25 to 35 range should not deter liver donation," concludes Dr. Rosenthal. The authors note that causes of graft loss, death, and donor steatosis could not be determined due to lack of donor biopsies. Rosenthal added, "Further research is needed to understand the impact of obesity on donor acceptability and how this affects pediatric liver transplant patients."
###
This study is published in Liver Transplantation. Media wishing to receive a PDF of this article may contact sciencenewsroom@wiley.com.
Full citation: "An Evaluation of the Impact of Donor BMI on Survival and Post-Transplant Obesity in Pediatric Liver Transplant Recipients." Emily Rothbaum Perito, Sue Rhee, Dave Glidden, John Paul Roberts, Philip Rosenthal. Liver Transplantation; Published Online: July 24, 2012 (DOI: 10.1002/lt.23438) Print Issue Date: August, 2012.
URL: http://onlinelibrary.wiley.com/doi/10.1002/lt.23438/abstract
About the Author: Dr. Philip Rosenthal is with the University of California, San Francisco's Benioff Children's Hospital. To arrange an interview with Dr. Rosenthal, please contact Juliana Bunim with UCSF at juliana.bunim@ucsf.edu or at 415-476-8810.
About the Journal:Liver Transplantation is published by Wiley on behalf of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. Since the first application of liver transplantation in a clinical situation was reported more than twenty years ago, there has been a great deal of growth in this field and more is anticipated. As an official publication of the AASLD and the ILTS, Liver Transplantation delivers current, peer-reviewed articles on surgical techniques, clinical investigations and drug research the information necessary to keep abreast of this evolving specialty. For more information, please visit Liver Transplantation.
About Wiley
Founded in 1807, John Wiley & Sons, Inc. has been a valued source of information and understanding for more than 200 years, helping people around the world meet their needs and fulfill their aspirations. Wiley and its acquired companies have published the works of more than 450 Nobel laureates in all categories: Literature, Economics, Physiology or Medicine, Physics, Chemistry, and Peace.
Our core businesses publish scientific, technical, medical, and scholarly journals, encyclopedias, books, and online products and services; professional/trade books, subscription products, training materials, and online applications and Web sites; and educational materials for undergraduate and graduate students and lifelong learners. Wiley's global headquarters are located in Hoboken, New Jersey, with operations in the U.S., Europe, Asia, Canada, and Australia. The Company's Web site can be accessed at http://www.wiley.com. The Company is listed on the New York Stock Exchange under the symbols JWa and JWb.
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Obese donors increase risk of death for pediatric liver transplant recipientsPublic release date: 1-Aug-2012 [ | E-mail | Share ]
Contact: Dawn Peters sciencenewsroom@wiley.com 781-388-8408 Wiley
Children undergoing liver transplantation are at greater risk of graft loss and death from adult organ donors who are severely obese according to research published in the August issue of Liver Transplantation, a journal of the American Association for the Study of Liver Diseases. The study, funded in part by a grant from the National Institutes of Health (NIH), found that pediatric donor body mass index (BMI) did not increase mortality risk in this pediatric population.
Obesity is a global health concern. A 2008 report from the World Health Organization (WHO) estimates that 1.4 billion adults were overweight, and of these 200 million men and 300 million women were classified as obese. WHO also reports that more than 40 million children under the age of five were overweight in 2010. In the U.S., rates of being overweight or obese have risen in children and now exceed 30% say experts.
Prior research shows the prevalence of overweight and obese donors to adult liver transplant recipients has increased during the last two decades. "Donor BMI is associated with post-transplant obesity, but not survival rates of adult liver recipients," explains lead author Dr. Philip Rosenthal, from the University of California, San Francisco's Benioff Children's Hospital. "Our study is the first to evaluate the impact of donor BMI on pediatric liver transplant recipients."
Using data from the United Network for Organ Sharing (UNOS), researchers identified 3788 pediatric liver transplants between 2004 and 2010. Analysis indicates that adult donor BMI 25-35 kg/m2 was not associated with graft loss or mortality in pediatric liver recipients. However, adult donors with a BMI greater than 35 kg/m2 increased the risk of graft loss and death in children receiving livers, after adjusting for other recipient, donor, and transplant risk factors. The authors found that pediatric donor BMI was not associated with graft or patient survival.
"While we found it common for adult donors to be overweight or obese, our analysis suggests that BMI in the 25 to 35 range should not deter liver donation," concludes Dr. Rosenthal. The authors note that causes of graft loss, death, and donor steatosis could not be determined due to lack of donor biopsies. Rosenthal added, "Further research is needed to understand the impact of obesity on donor acceptability and how this affects pediatric liver transplant patients."
###
This study is published in Liver Transplantation. Media wishing to receive a PDF of this article may contact sciencenewsroom@wiley.com.
Full citation: "An Evaluation of the Impact of Donor BMI on Survival and Post-Transplant Obesity in Pediatric Liver Transplant Recipients." Emily Rothbaum Perito, Sue Rhee, Dave Glidden, John Paul Roberts, Philip Rosenthal. Liver Transplantation; Published Online: July 24, 2012 (DOI: 10.1002/lt.23438) Print Issue Date: August, 2012.
URL: http://onlinelibrary.wiley.com/doi/10.1002/lt.23438/abstract
About the Author: Dr. Philip Rosenthal is with the University of California, San Francisco's Benioff Children's Hospital. To arrange an interview with Dr. Rosenthal, please contact Juliana Bunim with UCSF at juliana.bunim@ucsf.edu or at 415-476-8810.
About the Journal:Liver Transplantation is published by Wiley on behalf of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. Since the first application of liver transplantation in a clinical situation was reported more than twenty years ago, there has been a great deal of growth in this field and more is anticipated. As an official publication of the AASLD and the ILTS, Liver Transplantation delivers current, peer-reviewed articles on surgical techniques, clinical investigations and drug research the information necessary to keep abreast of this evolving specialty. For more information, please visit Liver Transplantation.
About Wiley
Founded in 1807, John Wiley & Sons, Inc. has been a valued source of information and understanding for more than 200 years, helping people around the world meet their needs and fulfill their aspirations. Wiley and its acquired companies have published the works of more than 450 Nobel laureates in all categories: Literature, Economics, Physiology or Medicine, Physics, Chemistry, and Peace.
Our core businesses publish scientific, technical, medical, and scholarly journals, encyclopedias, books, and online products and services; professional/trade books, subscription products, training materials, and online applications and Web sites; and educational materials for undergraduate and graduate students and lifelong learners. Wiley's global headquarters are located in Hoboken, New Jersey, with operations in the U.S., Europe, Asia, Canada, and Australia. The Company's Web site can be accessed at http://www.wiley.com. The Company is listed on the New York Stock Exchange under the symbols JWa and JWb.
[ | E-mail | Share ]
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Presumptive Republican presidential nominee Mitt Romney had another diplomatic misstep ? this time in Israel. The Romney campaign pushed back, disputing the reporting of Romney's comments. NBC's Peter Alexander reports.
By NBC News staff and wire reports
WARSAW, Poland --?Mitt Romney prepared to speak about U.S.-Poland ties on Tuesday, capping a week-long foreign tour that the presumptive Republican nominee had hoped would project the image of a leader ready to stand on the world's stage but instead became mired in controversy?after alleged missteps in Britain and Israel.
Romney was set to deliver a foreign policy speech in Warsaw at 6:15 a.m. ET at the end of his three-nation tour that began last week in Britain and took him to Israel.
The two-day trip to Poland is aimed at Polish-American and Catholic voters in the United States and will highlight Romney's stance toward Russia. He has labeled Russia as America's "No. 1 geopolitical foe," a characterization that's not unwelcome in a country that still fears Russia. Poles generally have been skeptical of President Barack Obama's "reset" with Russia, and Romney has cited Polish concerns in his criticism of Obama.
He will deliver his remarks in a deeply Roman Catholic country that for years has favored Republicans over Democrats. This is partly a legacy of President Ronald Reagan, whose efforts helped bring down communism across Eastern Europe, for which Poles remain grateful.
Poland has been a stalwart U.S. ally and significant contributor to military operations in Iraq and Afghanistan. As a former Soviet Bloc nation that has been subjugated by bigger European powers throughout history, it remains particularly worried about Russian policy.
Romney angers Palestinians Earlier, Romney was forced to fight off controversy after he called Jerusalem the Israeli capital and said later that differences in culture powered Israel's economic success compared with the Palestinians.
Both comments angered Palestinian leaders, just days after Romney annoyed Britons during a stop in London by questioning their readiness to host the Olympic Games.
Romney compliments Olympic preparation after tizzy in British press
The United States is the dominant broker in efforts -- paralyzed since 2008 -- to set up a Palestinian state through negotiations with Israel, and Palestinian leaders do not want to antagonize key players, including Romney.
Candidate Mitt Romney, who was slammed by the British media for comments he made about London's preparedness for the Olympics, now says that "after being here a couple days ? ?I'm absolutely convinced that the people here are ready for the Games."
However, Romney's comments on Sunday about Jerusalem prompted a strong response.
More on London 2012: Hosting the Olympic Games
The Palestinians want to establish a capital in east Jerusalem, captured and annexed by Israel in 1967. Most of the world, including the United States, does not recognize the annexation. Every U.S. administration since Lyndon Johnson has decided to keep the American embassy in Tel Aviv.
McCain: Israeli-Palestinian differences have 'nothing to do with cultures'
But on Sunday, Romney said flat out that Jerusalem is Israel's capital and strongly suggested he would move the U.S. Embassy to Jerusalem if he were president, supporting two key Israeli demands.
The fate of Jerusalem is one of the main sticking points in Israeli-Palestinian negotiations. Israeli Prime Minister Benjamin Netanyahu has said he will not give up any part of the city, taking a harder line than two of his predecessors who were ready to discuss partition.
Previous U.S. presidential candidates, including then-Sen. Obama in June 2008, have referred to Jerusalem as Israel's capital ahead of elections, only to row back when taking power and suggest the issue should be resolved by negotiations.
Romney: US has duty to protect Israel
Seeking American Jewish and fundamentalist Christian votes, Romney has criticized Obama on Israel, alleging last year that the president had "thrown Israel under a bus" in pushing hard for a two-state solution between Israel and the Palestinians.
In 2008, Obama won 78 percent of the Jewish vote, a lead into which Romney's campaign would love to make inroads.
Romney points to 'culture' gap Romney pointed to the big difference in wealth between Israel and the Palestinians and suggested Israel's culture was the reason for the gap.
More coverage of the Middle East and North Africa on NBCNews.com
"If you could learn anything from the economic history of the world, it's this: culture makes all the difference," he told a fundraising event in Jerusalem.
GOP presidential hopeful Mitt Romney sparked a political firestorm during an interview with NBC's Brian Williams, in which he questioned whether London was ready for the Olympics. NBC's Peter Alexander reports.
The chief Palestinian negotiator, Saeb Erekat said that Romney's comments amounted to "a racist statement that shows a lack of knowledge."
He added, "Everyone knows that the Palestinians cannot reach their full potential given the Israeli restrictions imposed on them."
Mitt Romney visits Western Wall, one of holiest sites in Judaism
A senior aide to Palestinian President Mahmoud Abbas, Nabil Abu Rdeineh, said Romney's statements were unhelpful, stood in the way of a peace settlement and "contradict the previous positions held by the American administration."
Sen. John McCain (R-Ariz.), a chief Romney foreign policy surrogate, appeared to differ with Romney even as he tried to defend him.
"I am sure that Gov. Romney was not talking about difference in cultures, or difference in anybody superior or inferior," McCain said Monday in Tampa, Fla. "What I'm sure Gov. Romney was talking was that the Israeli economy has grown and prospered in a dramatic fashion. And unfortunately, the Palestinians have not had that same economic development."
White House: Some 'scratching their heads' over Romney comments
McCain continued:?"And that goes to the leadership of the Palestinians. ... And we also know that the Palestinian people have not been blessed with the kind of government that has lower regulations, less taxes, entrepreneurship, which have caused the Israeli economy to be one of the world's most successful. It has nothing to do with cultures. It has nothing to do with superiority or inferiority."
In Jerusalem Sunday, Mitt Romney said the U.S. should "employ any and all measures to dissuade the Iranian regime from its nuclear course." NBC's Peter Alexander reports.
Bumpy international trip Despite efforts to contain controversy, Tuesday was another bumpy day on an international trip aimed at showing U.S. voters that the former governor of Massachusetts can handle foreign policy, an area where his election rival Obama has a lead in opinion polls.
Romney received words of encouragement on his visit to Poland on Monday from Lech Walesa, a former union leader and ex-Polish president, who said: "I wish you to be successful because this success is needed for the United States of course, but for Europe and the rest of the world too. Governor Romney, get your success. Be successful."
Full international coverage on NBCNews.com
But Solidarity, the union led by Walesa in the 1980s that helped topple communism in Poland, distanced itself from Romney, who it said "supported attacks on trade unions and employees' rights."
Romney is set to meet with Polish Foreign Minister Radoslaw Sikorski before his speech on Tuesday.
NBC News staff, Reuters and The Associated Press contributed to this report.
Contact: Elizabeth Fernandez elizabeth.fernandez@ucsf.edu 415-502-6397 University of California - San Francisco
As moms have always known, a good night's sleep is crucial to good health -- and now a new study led by a UCSF researcher shows that poor sleep can reduce the effectiveness of vaccines.
The study is the first performed outside a sleep laboratory to show that sleep duration is directly tied to vaccine immune response, the authors said.
The study, conducted while the UCSF researcher was a doctoral student at the University of Pittsburgh, will appear in the August issue of the journal "SLEEP."
"With the emergence of our 24-hour lifestyle, longer working hours, and the rise in the use of technology, chronic sleep deprivation has become a way of life for many Americans," said lead author Aric Prather, PhD, a clinical health psychologist and Robert Wood Johnson Foundation Health & Society Scholar at UCSF and UC Berkeley.
"These findings should help raise awareness in the public health community about the clear connection between sleep and health," Prather said.
Research has shown that poor sleep can make one susceptible to illnesses such as upper respiratory infections. To explore whether sleep duration, sleep efficiency, and sleep quality assessed at home and not in a controlled sleep lab -- would impact immune processes important in the protection against infection, the researchers investigated the antibody response to hepatitis B vaccinations on adults in good health. Antibodies are manufactured by the immune system to identify and neutralize foreign objects such as viruses.
The study involved 125 people (70 women, 55 men) between the ages of 40 and 60. All were nonsmokers in relatively good health, and all lived in Pennsylvania the study was conducted at the University of Pittsburgh. Each participant was administered the standard three-dose hepatitis B vaccine; the first and second dose were administered a month apart, followed by a booster dose at six months.
Antibody levels were measured prior to the second and third vaccine injection and six months after the final vaccination to determine whether participants had mounted a "clinically protective response."
All the participants completed sleep diaries detailing their bedtime, wake time and sleep quality, while 88 subjects also wore electronic sleep monitors known as actigraphs.
The researchers found that people who slept fewer than six hours on average per night were far less likely to mount antibody responses to the vaccine and thus were far more likely (11.5 times) to be unprotected by the vaccine than people who slept more than seven hours on average. Sleep quality did not affect response to vaccinations.
Of the 125 participants, 18 did not receive adequate protection from the vaccine. "Sleeping fewer than six hours conferred a significant risk of being unprotected as compared with sleeping more than seven hours per night," the scientists wrote.
The researchers stressed that sleep plays an important role in the regulation of the immune system. A lack of sleep, they said, may have detrimental effects on the immune system that are integral to vaccine response.
The National Sleep Foundation recommends seven to nine hours sleep a night. (For tips on a better night's sleep, see: http://www.ucsfhealth.org/education/tips_for_a_better_nights_sleep/index.html)
"Based on our findings and existing laboratory evidence, sleep may belong on the list of behavioral risk factors that influence vaccination efficacy," said Prather who in September will join the UCSF faculty as an assistant professor in the Department of Psychiatry. "While there is more work to be done in this area, in time physicians and other health care professionals who administer vaccines may want to consider asking their patients about their sleep patterns, since lack of sleep may significantly affect the potency of the vaccination."
###
The study's co-authors are Martica Hall, PhD, Jacqueline Fury, BS, Diana C. Ross, MSN, RN, Matthew Muldoon, MD, MPH, and Anna Marsland, PhD, of the University of Pittsburgh; and Sheldon Cohen, PhD of Carnegie Mellon University.
Financial support for the study was provided by a grant from the National Institute of Nursing Research (NR008237) and by a National Institute of Health fellowship to Prather.
UCSF is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care.
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Contact: Elizabeth Fernandez elizabeth.fernandez@ucsf.edu 415-502-6397 University of California - San Francisco
As moms have always known, a good night's sleep is crucial to good health -- and now a new study led by a UCSF researcher shows that poor sleep can reduce the effectiveness of vaccines.
The study is the first performed outside a sleep laboratory to show that sleep duration is directly tied to vaccine immune response, the authors said.
The study, conducted while the UCSF researcher was a doctoral student at the University of Pittsburgh, will appear in the August issue of the journal "SLEEP."
"With the emergence of our 24-hour lifestyle, longer working hours, and the rise in the use of technology, chronic sleep deprivation has become a way of life for many Americans," said lead author Aric Prather, PhD, a clinical health psychologist and Robert Wood Johnson Foundation Health & Society Scholar at UCSF and UC Berkeley.
"These findings should help raise awareness in the public health community about the clear connection between sleep and health," Prather said.
Research has shown that poor sleep can make one susceptible to illnesses such as upper respiratory infections. To explore whether sleep duration, sleep efficiency, and sleep quality assessed at home and not in a controlled sleep lab -- would impact immune processes important in the protection against infection, the researchers investigated the antibody response to hepatitis B vaccinations on adults in good health. Antibodies are manufactured by the immune system to identify and neutralize foreign objects such as viruses.
The study involved 125 people (70 women, 55 men) between the ages of 40 and 60. All were nonsmokers in relatively good health, and all lived in Pennsylvania the study was conducted at the University of Pittsburgh. Each participant was administered the standard three-dose hepatitis B vaccine; the first and second dose were administered a month apart, followed by a booster dose at six months.
Antibody levels were measured prior to the second and third vaccine injection and six months after the final vaccination to determine whether participants had mounted a "clinically protective response."
All the participants completed sleep diaries detailing their bedtime, wake time and sleep quality, while 88 subjects also wore electronic sleep monitors known as actigraphs.
The researchers found that people who slept fewer than six hours on average per night were far less likely to mount antibody responses to the vaccine and thus were far more likely (11.5 times) to be unprotected by the vaccine than people who slept more than seven hours on average. Sleep quality did not affect response to vaccinations.
Of the 125 participants, 18 did not receive adequate protection from the vaccine. "Sleeping fewer than six hours conferred a significant risk of being unprotected as compared with sleeping more than seven hours per night," the scientists wrote.
The researchers stressed that sleep plays an important role in the regulation of the immune system. A lack of sleep, they said, may have detrimental effects on the immune system that are integral to vaccine response.
The National Sleep Foundation recommends seven to nine hours sleep a night. (For tips on a better night's sleep, see: http://www.ucsfhealth.org/education/tips_for_a_better_nights_sleep/index.html)
"Based on our findings and existing laboratory evidence, sleep may belong on the list of behavioral risk factors that influence vaccination efficacy," said Prather who in September will join the UCSF faculty as an assistant professor in the Department of Psychiatry. "While there is more work to be done in this area, in time physicians and other health care professionals who administer vaccines may want to consider asking their patients about their sleep patterns, since lack of sleep may significantly affect the potency of the vaccination."
###
The study's co-authors are Martica Hall, PhD, Jacqueline Fury, BS, Diana C. Ross, MSN, RN, Matthew Muldoon, MD, MPH, and Anna Marsland, PhD, of the University of Pittsburgh; and Sheldon Cohen, PhD of Carnegie Mellon University.
Financial support for the study was provided by a grant from the National Institute of Nursing Research (NR008237) and by a National Institute of Health fellowship to Prather.
UCSF is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care.
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.